2 Vitamin D is responsible for appropriate calcium and phosphate balance and is required for normal bone growth and mineralization. Although animal experiments have indicated a difference in toxicity between vitamin D 3 and vitamin D 2, human studies have been inconclusive. The chemical structure differences between the two forms of vitamin D do not affect the metabolism or clinical responses once activated within the body. Therefore, cholecalciferol supplementation is essential. However, many individuals lack the ability to efficiently produce adequate stores of cholecalciferol. Thus, cutaneous production is highly efficient.
Brief exposure of approximately 20% of body surface area to sunlight is equivalent to ingesting 200 IU of cholecalciferol. In healthy individuals, 7-dehydrocholesterol in the skin is converted to cholecalciferol. Other dietary sources include fish liver oils, fatty fish, and eggs from hens that have been supplemented with vitamin D.Ĭholecalciferol is synthesized by the skin after exposure to sunlight. Various foods are fortified with vitamin D, including milk and cereal. 1 Furthermore, it induces a quicker response in the production of serum calcidiol that sustains longer at higher concentrations. Vitamin D is a fat-soluble vitamin and has two primary forms: cholecalciferol (vitamin D 3) and ergocalciferol (vitamin D 2). Cholecalciferol has a 10-fold increased potency as compared to ergocalciferol.
Overview of Cholecalciferol (Vitamin D3) Injection Dosage Strength of Cholecalciferol Injectionġ00,000 IU/mL 5 mL Vial General Information
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